Serological identification of human tumor antigens

Using the antibody repertoire of cancer patients for the systematic search for human tumor antigens, a plenitude of new human tumor antigens has been identified demonstrating that many human tumors elicit multiple immune responses in the autologous host. The abundance of serologically defined human...

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Bibliographic Details
Published in:	Current opinion in immunology Vol. 9; no. 5; pp. 709 - 716
Main Authors:	Sahin, Ugur, Türeci, Özlem, Pfreundschuh, Michael
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-10-1997
Subjects:	Antigens, Neoplasm - blood Antigens, Neoplasm - immunology Humans Serologic Tests CTA cancer/testis antigen CEBP CCAAT enhancer binding protein RT-PCR reverse-transcriptase polymerase chain reaction SEREX serological identification of antigens by recombinant expression cloning CTL cytotoxic T lymphocyte PCM pericentriolar material
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Summary:	Using the antibody repertoire of cancer patients for the systematic search for human tumor antigens, a plenitude of new human tumor antigens has been identified demonstrating that many human tumors elicit multiple immune responses in the autologous host. The abundance of serologically defined human tumor antigens facilitates the identification of T cell dependent antigens and provides a basis for peptide and gene therapy vaccine strategies in a wide variety of human cancers.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0952-7915 1879-0372
DOI:	10.1016/S0952-7915(97)80053-2