Wegener's granulomatosis followed by development of sarcoidosis

Although both Wegener's granulomatosis and sarcoidosis are considered granulomatous disorders, their clinical courses differ markedly, and typically patients with these two diseases are readily distinguishable. We report an unusual case in which the patient presented with a systemic vasculitis...

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Bibliographic Details
Published in:	American journal of kidney diseases Vol. 28; no. 6; p. 893
Main Authors:	Ahuja, T S, Mattana, J, Valderrama, E, Sankaran, R, Singhal, P C, Wagner, J D
Format:	Journal Article
Language:	English
Published:	United States 01-12-1996
Subjects:	Adult Biopsy Glomerulonephritis - complications Glomerulonephritis - pathology Granulomatosis with Polyangiitis - complications Granulomatosis with Polyangiitis - drug therapy Granulomatosis with Polyangiitis - pathology Humans Kidney - pathology Lung - pathology Male Nasal Mucosa - pathology Sarcoidosis - complications Sarcoidosis - pathology Skin - pathology
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Summary:	Although both Wegener's granulomatosis and sarcoidosis are considered granulomatous disorders, their clinical courses differ markedly, and typically patients with these two diseases are readily distinguishable. We report an unusual case in which the patient presented with a systemic vasculitis consistent with Wegener's granulomatosis that remitted with therapy and then, months later, developed sarcoidosis. This is the first case report of the sequential development of the two diseases. We review the relationship of vasculitis to sarcoidosis and speculate on the etiopathogenesis that might link the two.
ISSN:	0272-6386
DOI:	10.1016/S0272-6386(96)90390-X