Synthesis and antibacterial activity of some new heterocycles incorporating phthalazine

3-(1,4-Dioxo-3,4,4e,5,10,10a-hexahydro-1 H-5,10-benzeno-benzo[g]phthalazin-2-yl)-3-oxo-propiononitrile ( 1) was utilized as key intermediate for the synthesis of some new iminocoumarin 2, chromenone 3, aminothiazole 4, triazepine 5a, b and 6, hydrazono-propiononitrile 7, pyridopyrazotriazine 8, mono...

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Bibliographic Details
Published in:	European journal of medicinal chemistry Vol. 44; no. 11; pp. 4448 - 4454
Main Authors:	Khalil, A.M., Berghot, M.A., Gouda, M.A.
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Masson SAS 01-11-2009 Elsevier
Subjects:	Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Azepines - chemical synthesis Azepines - chemistry Azepines - pharmacology Bacillus thuringiensis Bacillus thuringiensis - drug effects Biological and medical sciences Coumarine Coumarins - chemical synthesis Coumarins - chemistry Coumarins - pharmacology Escherichia coli Escherichia coli - drug effects Ketene N,S-acetal Ketene S,S-diacetal Medical sciences Mice Microbial Sensitivity Tests Molecular Structure Pharmacology. Drug treatments Phthalazine Phthalazines - chemical synthesis Phthalazines - chemistry Phthalazines - pharmacology Triazepine Triazine Triazines - chemical synthesis Triazines - chemistry Triazines - pharmacology Ketene S,S-diacetal Phthalazine Bacillus thuringiensis Escherichia coli Triazine Coumarine Triazepine Ketene N,S-acetal Coumarine derivatives Lactone Bacillaceae In vitro Thiohemiaminal Biological activity Ketenes Phthalazine derivatives Dithioacetal Bacillales Triazine derivatives Bacteria Antibacterial agent Chemical synthesis Enterobacteriaceae
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Summary:	3-(1,4-Dioxo-3,4,4e,5,10,10a-hexahydro-1 H-5,10-benzeno-benzo[g]phthalazin-2-yl)-3-oxo-propiononitrile ( 1) was utilized as key intermediate for the synthesis of some new iminocoumarin 2, chromenone 3, aminothiazole 4, triazepine 5a, b and 6, hydrazono-propiononitrile 7, pyridopyrazotriazine 8, monobromo 9, dibromo 10 quinoxaline 11, ketene N,S-acetal 13, ketene S,S-diacetal 17 and 18a, b and methyl dithioate 20 derivatives, respectively. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral studies. Representative compounds of the synthesized product were tested and evaluated as antibacterial agent. [Display omitted]
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0223-5234 1768-3254
DOI:	10.1016/j.ejmech.2009.06.003