Cyclic Neutropenia: The Relationship Between Urine Granulocyte Colony Stimulating Activity and Neutrophil Count

Cyclic Neutropenia: The Relationship Between Urine Granulocyte Colony Stimulating Activity and Neutrophil Count

Urinary colony stimulating activity (CSA) has been studied in a 70-yr-old female with chronic cyclic neutropenia of unknown cause. Changes in urinary CSA were correlated with absolute granulocyte counts and were found to be highest when the granulocyte count was high or falling. It is suggested, on...

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Bibliographic Details
Published in:Blood Vol. 41; no. 1; pp. 79 - 84
Main Authors: Mangalik, Aroop, Robinson, W.A.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-01-1973
Subjects:
Aged
Agranulocytosis
Animals
Bone Marrow Cells
Cells, Cultured
Culture Media
Female
Hematopoiesis
Humans
Leukocyte Count
Mice
Neutrophils
Urine - cytology
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Summary:Urinary colony stimulating activity (CSA) has been studied in a 70-yr-old female with chronic cyclic neutropenia of unknown cause. Changes in urinary CSA were correlated with absolute granulocyte counts and were found to be highest when the granulocyte count was high or falling. It is suggested, on the basis of this and other data, that granulopoiesis, at least in part, may be regulated by a positive feedback control mechanism.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V41.1.79.79