Lithium inhibition of phosphofructokinase

The mode of action of lithium in prophylaxis of recurrent affective disorder is unknown although it has been suggested that lithium might compete with magnesium in magnesium dependent processes. We have previously shown pyruvate kinase to be inhibited by lithium and the present study demonstrates a...

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Bibliographic Details
Published in:	Journal of inorganic biochemistry Vol. 14; no. 3; p. 275
Main Authors:	Kajda, P K, Birch, N J
Format:	Journal Article
Language:	English
Published:	United States 01-01-1981
Subjects:	Adenosine Triphosphate - metabolism Animals Dose-Response Relationship, Drug Fructosephosphates - metabolism Kinetics Lithium - pharmacology Magnesium - pharmacology Muscles - enzymology Phosphofructokinase-1 - antagonists & inhibitors Potassium - pharmacology Rabbits
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Summary:	The mode of action of lithium in prophylaxis of recurrent affective disorder is unknown although it has been suggested that lithium might compete with magnesium in magnesium dependent processes. We have previously shown pyruvate kinase to be inhibited by lithium and the present study demonstrates a small inhibition by lithium of phosphofructokinase that is also a major regulatory step in glycolysis. Inhibition of PFK was competitive with respect to ATP and magnesium and noncompetitive with respect to potassium and fructose-6-phosphate. Inhibition was enhanced at reduced concentrations of magnesium.
ISSN:	0162-0134
DOI:	10.1016/S0162-0134(00)80008-2