Nor- ent-kaurane diterpenes and hydroxylactones from Antennaria geyeri and Anaphalis margaritacea

• Published in: Phytochemistry (Oxford) Vol. 65; no. 18; pp. 2539 - 2543
• Main Authors: Ahmed, Ahmed A., Hussein, Taha A., Mahmoud, Ahmed A., Farag, Mohamed A., Paré, Paul W., Wojcińska, Małgorzata, Karchesy, Joe, Mabry, Tom J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-09-2004
• Subjects: Anaphalis; Anaphalis margaritacea; Antennaria; Antennaria geyeri; Antibacterial; antibacterial properties; Asteraceae; Asteraceae - chemistry; Bacillus cereus; chemical structure; Diterpenes; Diterpenes, Kaurane - chemistry; Diterpenes, Kaurane - isolation & purification; diterpenoids; Escherichia coli; human health; Hydroxylactones; Hydroxylation; kaurane; lactones; Lactones - chemistry; Lactones - isolation & purification; Magnetic Resonance Spectroscopy; Molecular Structure; nor- ent-kaurane; phytochemicals; plant extracts; Pseudomonas aeruginosa; spectral analysis; Staphylococcus aureus; stereochemistry; Oregon; Hydroxylactones; Antennaria geyeri; Anaphalis margaritacea; Asteraceae; nor- ent-kaurane; Diterpenes; Antibacterial
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2004.08.002

Antennaria geyeri afforded nor-
ent-kaurane diterpenes with antibacterial activity.
Anaphalis margaritacea afforded two hydroxy lactones. Structures were elucidated on the basis of 1D and 2D NMR analysis, IR and CIMS.
In a study of Pacific Northwest plants of the Asteraceae family, a nor-
ent-kaurane diterpene and a known diterpene, both displaying antibacterial activities, were isolated together with scopoletin and sitosterol-3-
O-β-glucopyranoside from the aerial parts of
Antennaria geyeri.
Anaphalis margaritacea afforded two hydroxylactones. The structures were established by one and two dimensional NMR techniques, IR and CIMS.