Distribution of CTLA-4 polymorphisms in allergic asthma

• Published in: International Archives of Allergy and Immunology Vol. 141; no. 3; pp. 223 - 229
• Main Authors: Jasek, Monika, Łuszczek, Wioleta, Obojski, Andrzej, Winiarska, Beata, Hałubek, Katarzyna, Nowak, Izabela, Mańczak, Maria, Wiśniewski, Andrzej, Pawlik, Andrzej, Jonkisz, Anna, Lebioda, Arleta, Majorczyk, Edyta, Dobosz, Tadeusz, Kuśnierczyk, Piotr
• Format: Journal Article
• Language: English
• Published: Switzerland 01-01-2006
• Subjects: Antigens, CD - genetics; Antigens, CD - immunology; Antigens, Differentiation - genetics; Antigens, Differentiation - immunology; Asthma - epidemiology; Asthma - genetics; CTLA-4 Antigen; Gene Frequency; Humans; Hypersensitivity - genetics; Immunosuppressive Agents - immunology; Poland - epidemiology; Polymorphism, Genetic; Poland
• ISSN: 1018-2438; 1365-2567
• DOI: 10.1159/000095292

The CTLA-4 molecule is an important negative regulator of T cell activation. It is encoded on chromosome 2q33 and found to be associated with several allergic phenotypes including asthma. However, the association of CTLA-4 gene polymorphisms with allergic asthma is still controversial and therefore was the subject of this study.
By PCR-RFLP, the distribution of three single nucleotide polymorphisms (SNPs), -1147 C/T, -318 C/T, and +49 A/G, was examined in 219 Polish Caucasoid patients diagnosed with allergic asthma and in 102 ethnically matched healthy control individuals. (AT)(n) microsatellite polymorphism was also tested in the same individuals.
No statistically significant differences in SNPs or microsatellite allele, genotype or haplotype frequencies between patients and controls were found.
CTLA-4 polymorphisms do not seem to be a risk factor for allergic asthma in Poles.