A pilot randomized clinical trial of γ-tocopherol supplementation on wood smoke–induced neutrophilic and eosinophilic airway inflammation

• Published in: The journal of allergy and clinical immunology. Global Vol. 2; no. 4; p. 100177
• Main Authors: Peden, David B., Almond, Martha, Brooks, Christian, Robinette, Carole, Wells, Heather, Burbank, Allison, Hernandez, Michelle, Hinderliter, Alan, Caughey, Melissa, Jiang, Qing, Wang, Qianyue, Li, Haolin, Zhou, Haibo, Alexis, Neil
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-11-2023; Elsevier
• Subjects: air pollution; asthma; Brief Report; environmental lung disease; eosinophils; neutrophils; wood smoke particles; γ-Tocopherol; γT; γ-CEHC; αT; O3; PMNs; eosinophils; asthma; γ-Tocopherol; environmental lung disease; wood smoke particles; WSP; IRB; air pollution; neutrophils
• ISSN: 2772-8293; 2772-8293
• DOI: 10.1016/j.jacig.2023.100177

Air pollutants, including particulates from wood smoke, are a significant cause of exacerbation of lung disease. γ-Tocopherol is an anti-inflammatory isoform of vitamin E that has been shown to reduce allergen-, ozone-, and endotoxin-induced inflammation.
The objective of this study was to determine whether γ-tocopherol would prevent experimental wood smoke–induced airway inflammation in humans.
This was a randomized, placebo-controlled clinical trial testing the effect of a short course of γ-tocopherol–enriched supplementation on airway inflammation following a controlled exposure to wood smoke particulates.
Short-course γ-tocopherol intervention did not reduce wood smoke–induced neutrophilic airway inflammation, but it did prevent wood smoke–induced eosinophilic airway inflammation.
γ-Tocopherol is a potential intervention for exacerbation of allergic airway inflammation, but further study examining longer dosing periods is required.