Effects of intratympanic dexamethasone on noise-induced hearing loss: An experimental study

• Published in: American journal of otolaryngology Vol. 39; no. 1; pp. 71 - 73
• Main Authors: Gumrukcu, Sait Serdar, Topaloglu, İlhan, Salturk, Ziya, Tutar, Belgin, Atar, Yavuz, Berkiten, Güler, Göker, Ayşe Enise
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-01-2018; Elsevier Limited
• Subjects: Acoustic emission; Acoustic noise; Acoustic trauma; Acoustics; Animals; Dexamethasone; Dexamethasone - administration & dosage; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug dosages; Ear diseases; Ears & hearing; Evoked Potentials, Auditory, Brain Stem - drug effects; Female; Hair; Hearing; Hearing loss; Hearing Loss, Noise-Induced - diagnosis; Hearing Loss, Noise-Induced - drug therapy; Hearing protection; Injections, Intralesional; Intratympanic steroid; Neck; Noise; Noise control; Noise induced hearing loss; Noise levels; Oto-acoustic emission; Otoacoustic Emissions, Spontaneous - drug effects; Random Allocation; Rats; Rats, Wistar; Recovery of Function; Reference Values; Saline solutions; Steroids; Treatment Outcome; Tympanic Membrane - drug effects; Ventilation; Rats; Acoustic trauma; Intratympanic steroid; Noise induced hearing loss; Oto-acoustic emission
• ISSN: 0196-0709; 1532-818X
• DOI: 10.1016/j.amjoto.2017.10.011

Aim of the study was to evaluate the effect of intratympanic steroid treatment on hearing based on oto-acoustic emission.
A total of 16 healthy female Wistar albino rats weighing were used in this study. They were divided in to 2 groups and each group was exposed to noise at 110dB for 25min to induce acoustic trauma. Intratympanic dexamethasone was administered to the middle ears of animals in the experimental group on the same day as exposure to noise. The control group was given 0.09% saline solution. Distortion product otoacoustic emission measurements were performed on days 7 and 10.
There were no differences between the emission results of two groups before treatment at 4004, 4761, 5652, 6726, and 7996Hz. There were significant group differences on measurement days 7 and 10 at all frequencies.
Our study revealed a significant difference in DPOAE measurements on days 7 and 10 between the experimental and control groups. We detected a positive effect of dexamethasone on noise-induced hearing loss.