Combined approach as an effective method in the prevention of severe ovarian hyperstimulation syndrome

• Published in: European journal of obstetrics & gynecology and reproductive biology Vol. 97; no. 2; pp. 208 - 212
• Main Authors: Isik, Ahmet Zeki, Vicdan, Kubilay
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01-08-2001; Elsevier
• Subjects: Adult; Albumin; Biological and medical sciences; Birth control; Chorionic Gonadotropin - administration & dosage; Estradiol - blood; Female; Fertilization in Vitro; Follicle Stimulating Hormone - administration & dosage; Gynecology. Andrology. Obstetrics; Hormones. Endocrine system; Humans; Infusions, Intravenous; IVF; Medical sciences; Menotropins - administration & dosage; Oocytes; Ovarian hyperstimulation syndrome; Ovarian Hyperstimulation Syndrome - prevention & control; Pharmacology. Drug treatments; Prevention; Progesterone - administration & dosage; Serum Albumin - administration & dosage; Sperm Injections, Intracytoplasmic; Sterility. Assisted procreation; Tissue and Organ Harvesting; Turkey; Turkey; Prevention; IVF; Albumin; Ovarian hyperstimulation syndrome; Intravenous administration; Assisted procreation; Glycoprotein hormone; Fecundation; Progestagen; Human chorionic gonadotrophin; Female; Human; Subfertility; Gonadotropin; In vitro; Ovarian hormone; Placental hormone; Female genital diseases; Ovarian diseases; Follow up study; Perfusion; Combined treatment; Progesterone; Sex steroid hormone; Severe; Therapeutic protocol
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/S0301-2115(00)00539-X

The purpose of this study was to evaluate the effectiveness of combined approach on the prevention of severe ovarian hyperstimulation syndrome (OHSS) in high risk patients undergoing controlled ovarian hyperstimulation for IVF. The combined approach consisted of: (1) step-down administration of gonadotropins; (2) lowering the dose of human chorionic gonadotropin; (3) intravenous albumin infusion at the time of oocyte retrieval and (4) progesterone use for luteal support. Total of 87 high risk patients with a serum estradiol level >11,010
pmol/l or 3000
pg/ml on HCG day were managed by this combined approach and their results were compared with 274 low risk patients. In all high risk patients, the gonadotrophin dose were decreased starting as early as on day 4 of ovarian stimulation as necessary, ovulation was triggered by a decreased HCG dose of 5000–7000
IU according to the level of estradiol, intravenous infusion of 20% human albumin, 50–100
ml were given just 1
h before the oocyte retrieval and luteal support was provided either by 50
mg progesterone in oil, IM or 600
mg micronized progesterone orally or vaginally until the day of β-HCG determination. All patients were followed by serial ultrasonographic examinations and complete blood count analysis after embryo transfer to detect the early signs of OHSS and to allow early intervention. Age and duration of infertility were similar in both groups. Although the number of gonadotrophin ampoules used (22.7±4.7 versus 27.8±3.7;
P<0.05) was significantly lower, estradiol levels (16,764±6936
pmol/l versus 8870±2456
pmol/l;
P<0.05) and mean number of oocytes (18.3±5.9 versus 10.6±5.4;
P<0.05) were significantly higher in study group. There was no significant difference between groups in terms of the mean number of transferred embryos (3.2±1.1 versus 3.4±1.1) and rate of pregnancies (50.5% versus 40.1%). There was only one moderate and no severe OHSS case in the high risk group, while five moderate and one severe OHSS cases developed in the control group consisting of low risk patients. In conclusion, intravenous albumin combined with low dose HCG, early step-down administration of gonadotropins and progesterone use for luteal support, so called combined approach, proved to be effective in the prevention of severe ovarian hyperstimulation syndrome in documented high risk patients.