Corneal endothelial permeability after anterior chamber silicone oil

• Published in: Ophthalmology (Rochester, Minn.) Vol. 97; no. 12; p. 1671
• Main Authors: Norman, B C, Oliver, J, Cheeks, L, Hull, D S, Birnbaum, D, Green, K
• Format: Journal Article
• Language: English
• Published: United States 01-12-1990
• Subjects: Animals; Anterior Chamber; Dextrans - metabolism; Endothelium, Corneal - drug effects; Endothelium, Corneal - metabolism; Endothelium, Corneal - ultrastructure; Intraocular Pressure - drug effects; Inulin - metabolism; Permeability; Rabbits; Silicone Oils - administration & dosage; Silicone Oils - pharmacology; Viscosity
• ISSN: 0161-6420
• DOI: 10.1016/S0161-6420(90)32374-6

One of six silicone oils, differing in both viscosity and manufacture, was infused into the anterior chambers of rabbit eyes. Polydimethylsiloxane oil, 5000 cps, caused an increased corneal endothelial permeability to inulin and dextran at 24, 96, and 168 hours after placement into the eye. Intraocular pressures were slightly elevated in the experimental eyes, compared with contralateral controls, at 24 and 144 hours after infusion. The effects of five other oils on corneal endothelial permeability were examined 168 hours after infusion. All oils increased permeability and caused thinning of endothelial cells, together with the appearance of a retrocorneal membrane, except Dow Corning Medical Fluid 360. The results indicated that contact of most silicone oils with corneal endothelium rapidly induces physiologic and morphologic changes.