Randomized Trial of Four Treatment Approaches for Actinic Keratosis

Actinic keratosis is common and can lead to squamous-cell cancer of the skin. In a randomized comparison of efficacy assessed by a dermatologist who was unaware of the treatment assignments, fluorouracil was significantly more effective than ingenol mebutate, photodynamic therapy, or imiquimod at 3...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 380; no. 10; pp. 935 - 946
Main Authors:	Jansen, Maud H.E, Kessels, Janneke P.H.M, Nelemans, Patty J, Kouloubis, Nina, Arits, Aimee H.M.M, van Pelt, Han P.A, Quaedvlieg, Patricia J.F, Essers, Brigitte A.B, Steijlen, Peter M, Kelleners-Smeets, Nicole W.J, Mosterd, Klara
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 07-03-2019
Subjects:	5-Fluorouracil Antiviral drugs Cream Dermatology Evidence-based medicine Imiquimod Keratosis Medical research Patients Photodynamic therapy Skin diseases Transdermal medication Netherlands
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Summary:	Actinic keratosis is common and can lead to squamous-cell cancer of the skin. In a randomized comparison of efficacy assessed by a dermatologist who was unaware of the treatment assignments, fluorouracil was significantly more effective than ingenol mebutate, photodynamic therapy, or imiquimod at 3 and 12 months after the end of treatment.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-News-2 ObjectType-Feature-3 content type line 23
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1811850