Antimicrobial flavonoids as a potential substitute for overcoming antimicrobial resistance

• Published in: Fitoterapia Vol. 146; pp. 104720 - 22
• Main Authors: Biharee, Avadh, Sharma, Aditi, Kumar, Amit, Jaitak, Vikas
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-10-2020; Elsevier Science Ltd
• Subjects: Anti-Bacterial Agents - pharmacology; Antimicrobial; Antimicrobial activity; Antimicrobial agents; Antimicrobial resistance; Bacteria - drug effects; Biofilm formation; Biofilms; Drug development; Drug metabolism; Drug resistance; Drug Resistance, Multiple, Bacterial; Drugs; Efflux; Endotoxins; Flavonoids; Flavonoids - pharmacology; Infections; Infectious diseases; Literature reviews; Microorganisms; Molecular Structure; Natural products; Nucleic acids; Phytochemicals - pharmacology; Quorum sensing; Synthesis; Virulence; Virulence factor; Virulence factors; Antimicrobial; Flavonoids; Quorum sensing; Antimicrobial resistance; Biofilm formation; Virulence factor
• ISSN: 0367-326X; 1873-6971
• DOI: 10.1016/j.fitote.2020.104720

Infectious diseases are the leading cause of death in 21st century due to antimicrobial resistance and scarcity of new molecules to undertake rising infections. There could be a multiple reasons behind antimicrobial resistance whether it is increased drug metabolism or bacterial endotoxins. The demand of effective medication is increasing day by day to treat microbial infections and combat antimicrobial resistance. In recent years most of the synthetic antimicrobials developed resistance so natural products could provide better options to fulfill this demand. There has been increasing interest in the research on flavonoids because various flavonoids were found to be effective against pathogenic microorganisms.
The objective of this article will be to explore antimicrobial activity of flavonoids with special focus on their possible mechanism of action.
The article reviewed recent literature related to flavonoids with antimicrobial activity, which were isolated from various sources and the compounds showing fairly good activity against tested microbial species were discussed.
By throughout literature review it has been found that flavonoids show antimicrobial effect by inhibiting virulence factors, efflux pump, biofilm formation, membrane disruption, cell envelop synthesis, nucleic acid synthesis, and bacterial motility inhibition.
Most of the antimicrobial drugs available now a days are ineffective due to development of resistance to them. Flavonoids have the potential to overcome this emerging crisis as this class of natural products showed the antimicrobial activity by different mechanisms than those of conventional drugs, so flavonoid could be an effective treatment of pathogenic infections.
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