Cell injury associated calcium oxalate crystalluria

Renal tubular cell damage, resulting in membranuria, was induced by the administration of subcutaneous gentamicin to male Sprague-Dawley rats. One group of rats received gentamicin only, while a second group was given gentamicin plus ethylene glycol in drinking water at a concentration which increas...

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Bibliographic Details
Published in:	The Journal of urology Vol. 144; no. 6; p. 1535
Main Authors:	Hackett, R L, Shevock, P N, Khan, S R
Format:	Journal Article
Language:	English
Published:	United States 01-12-1990
Subjects:	Animals Calcium Oxalate - urine Cell Membrane - drug effects Crystallization Ethylene Glycol Ethylene Glycols - adverse effects Gentamicins - adverse effects Kidney Calculi - chemically induced Kidney Calculi - urine Kidney Tubular Necrosis, Acute - chemically induced Kidney Tubular Necrosis, Acute - urine Kidney Tubules - drug effects Male Rats Rats, Inbred Strains
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Summary:	Renal tubular cell damage, resulting in membranuria, was induced by the administration of subcutaneous gentamicin to male Sprague-Dawley rats. One group of rats received gentamicin only, while a second group was given gentamicin plus ethylene glycol in drinking water at a concentration which increased urine oxalate but alone did not cause calcium oxalate crystalluria. Crystalluria occurred early in the combined treatment groups and persisted for the duration of the experiment. Crystalluria was not present in animals receiving gentamicin or ethylene glycol only. These results suggest that cellular fragments can serve as heterogeneous foci for the nucleation of calcium oxalate crystals.
ISSN:	0022-5347
DOI:	10.1016/S0022-5347(17)39793-8