Vesicle formation from hexasubstituted cyclophosphazenic derivatives

• Published in: International journal of pharmaceutics Vol. 183; no. 2; pp. 101 - 107
• Main Authors: Baroli, Biancamaria, Delogu, Giovanna, Fadda, Anna M, Podda, Gianni, Sinico, Chiara
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 25-06-1999; Elsevier
• Subjects: 1,6-Diphenyl-1,3,5-hexatriene; 5-Carboxyfluorescein; Biological and medical sciences; Cholesterol - chemistry; General pharmacology; Hexasubstituted cyclophosphazenes; Medical sciences; Membranes, Artificial; Microscopy, Electron; Niosomes; Organophosphorus Compounds - chemistry; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Sonication; Vesicles; Vesicles; 5-Carboxyfluorescein; Hexasubstituted cyclophosphazenes; 1,6-Diphenyl-1,3,5-hexatriene; Niosomes; Aggregation; Encapsulation; Vesicle; Pharmaceutical technology; Cyclic compound; Dosage form; Cyclophosphazene polymer; Drug carrier; Chemical synthesis; Niosome
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/S0378-5173(99)00024-1

Hexakis[butoxytris(ethoxy)]cyclophosphazene (
3a), hexakis[dodecyloxytetrakis (ethoxy)]cyclophosphazene (
3b) and hexakis[hexadecyloxyeicosanekis(ethoxy)]cyclophosphazene (
3c) were synthesised and their ability to form niosomes was studied. All synthesised compounds in the presence of cholesterol were shown to form vesicles, which aggregated strongly. To prevent aggregation, dicetylphosphate was used. The capacity of the sonicated and unsonicated niosomes to encapsulate hydrophile and lipophile molecules was also studied using carboxyfluorescein and diphenylhexatriene.