Neo-clerodane diterpenoids from Conyza pyrrhopappa Sch.Bip. ex A.Rich

Two hitherto unknown neo-clerodane-type diterpenoids along with twelve known compounds have been isolated from Conyza pyrrhopappa Sch.Bip. ex A.Rich, a medicinal plant traditionally used across tropical Africa to relieve fever. The structures of isolates have been elucidated by a combination of spec...

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Published in:	Natural product research Vol. 35; no. 19; pp. 3210 - 3219
Main Authors:	Bitchagno, Gabin Thierry M., Schüffler, Anja, Simo, Ingrid K., Krumb, Matthias, Tane, Pierre, Opatz, Till
Format:	Journal Article
Language:	English
Published:	Taylor & Francis 02-10-2021
Subjects:	Antimicrobial Asteraceae Conyza pyrrhopappa Cytotoxicity Isolation Neo-clerodanes Structure elucidation
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Abstract	Two hitherto unknown neo-clerodane-type diterpenoids along with twelve known compounds have been isolated from Conyza pyrrhopappa Sch.Bip. ex A.Rich, a medicinal plant traditionally used across tropical Africa to relieve fever. The structures of isolates have been elucidated by a combination of spectroscopic techniques. The crude extract and the isolated compounds were evaluated in the Hela-S3 cell line and in a panel of microorganisms (bacteria and fungi) at concentrations up to 50 µg/mL. The new compounds were inactive while the pentamethylated flavonoids showed low to significant activity against the cancer cell line used. However, none of the samples showed any activity against the tested microorganisms at this concentration. The present manuscript is the first investigation of the cytotoxicity of phytochemicals and extract from C. pyrrhopappa.
AbstractList	Two hitherto unknown neo-clerodane-type diterpenoids along with twelve known compounds have been isolated from Conyza pyrrhopappa Sch.Bip. ex A.Rich, a medicinal plant traditionally used across tropical Africa to relieve fever. The structures of isolates have been elucidated by a combination of spectroscopic techniques. The crude extract and the isolated compounds were evaluated in the Hela-S3 cell line and in a panel of microorganisms (bacteria and fungi) at concentrations up to 50 µg/mL. The new compounds were inactive while the pentamethylated flavonoids showed low to significant activity against the cancer cell line used. However, none of the samples showed any activity against the tested microorganisms at this concentration. The present manuscript is the first investigation of the cytotoxicity of phytochemicals and extract from C. pyrrhopappa.
Author	Simo, Ingrid K. Bitchagno, Gabin Thierry M. Krumb, Matthias Schüffler, Anja Opatz, Till Tane, Pierre
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Title	Neo-clerodane diterpenoids from Conyza pyrrhopappa Sch.Bip. ex A.Rich
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