Neo-clerodane diterpenoids from Conyza pyrrhopappa Sch.Bip. ex A.Rich

Two hitherto unknown neo-clerodane-type diterpenoids along with twelve known compounds have been isolated from Conyza pyrrhopappa Sch.Bip. ex A.Rich, a medicinal plant traditionally used across tropical Africa to relieve fever. The structures of isolates have been elucidated by a combination of spec...

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Bibliographic Details
Published in:	Natural product research Vol. 35; no. 19; pp. 3210 - 3219
Main Authors:	Bitchagno, Gabin Thierry M., Schüffler, Anja, Simo, Ingrid K., Krumb, Matthias, Tane, Pierre, Opatz, Till
Format:	Journal Article
Language:	English
Published:	Taylor & Francis 02-10-2021
Subjects:	Antimicrobial Asteraceae Conyza pyrrhopappa Cytotoxicity Isolation Neo-clerodanes Structure elucidation
Online Access:	Get full text
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Summary:	Two hitherto unknown neo-clerodane-type diterpenoids along with twelve known compounds have been isolated from Conyza pyrrhopappa Sch.Bip. ex A.Rich, a medicinal plant traditionally used across tropical Africa to relieve fever. The structures of isolates have been elucidated by a combination of spectroscopic techniques. The crude extract and the isolated compounds were evaluated in the Hela-S3 cell line and in a panel of microorganisms (bacteria and fungi) at concentrations up to 50 µg/mL. The new compounds were inactive while the pentamethylated flavonoids showed low to significant activity against the cancer cell line used. However, none of the samples showed any activity against the tested microorganisms at this concentration. The present manuscript is the first investigation of the cytotoxicity of phytochemicals and extract from C. pyrrhopappa.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1478-6419 1478-6427
DOI:	10.1080/14786419.2019.1690490