Conductimetric determination of reproterol HCl and pipazethate HCl and salbutamol sulphate in their pharmaceutical formulations

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 26; no. 3; pp. 379 - 386
• Main Authors: Issa, Y.M, Shoukry, A.F, El-Nashar, R.M
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01-10-2001; Elsevier Science
• Subjects: Albuterol - analysis; Albuterol - chemistry; Analysis; Asthmobronchin; Benzothiadiazines - analysis; Benzothiadiazines - chemistry; Biological and medical sciences; Chemistry, Pharmaceutical; Conductimetric titration; Drug Combinations; Electrochemistry; General pharmacology; Medical sciences; Metaproterenol - analogs & derivatives; Metaproterenol - analysis; Metaproterenol - chemistry; Pharmacology. Drug treatments; Pipazethate; Reproterol; Salbovent; Salbutamol; Selgon; Solubility; Theophylline - analogs & derivatives; Theophylline - analysis; Theophylline - chemistry; Salbovent; Asthmobronchin; Pipazethate; Reproterol; Selgon; Salbutamol; Conductimetric titration; Drug combination; Bronchodilator; Solubility; Pipazetate; Associative ionization; Syrup; Drop; Analysis method; Conductometry; Dosage form; Tablet; Xanthine derivatives; Quantitative analysis
• ISSN: 0731-7085; 1873-264X
• DOI: 10.1016/S0731-7085(01)00415-0

A simple and sensitive conductimetric method for the determination of salbutamol sulphate and reproterol and pipazethate hydrochlorides is presented based on their ion associates with phosphotungstic and phosphomolybdic acids. The effect of solvent, molar ratio, reagent concentration and temperature were studied, and the solubility products of the formed ion associates were calculated. The method was applied to the determination of the drugs in their pure state or pharmaceutical preparations with mean recovery values of 99.82–100.54, 99.75–100.12 and 99.95–100.40%, and coefficient of variation 0.28–0.52, 0.16–0.36 and 0.19–0.33 for salbutamol sulphate, reproterol HCl and pipazathate HCl, respectively.