The Role of the t-PA I/D and PAI-1 4G/5G Polymorphisms in African-American Adults With a Diagnosis of Myocardial Infarction or Venous Thromboembolism

• Published in: Thrombosis research Vol. 99; no. 3; pp. 223 - 230
• Main Authors: Hooper, W.Craig, Lally, Cathy, Austin, Harland, Renshaw, Mary, Dilley, Anne, Wenger, Nanette Kass, Phillips, Donald J, Whitsett, Carolyn, Rawlins, Peggy, Evatt, Bruce L
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 01-08-2000; Elsevier Science
• Subjects: Adult; African Americans; African Continental Ancestry Group - genetics; Aged; Aged, 80 and over; Biological and medical sciences; Cardiology. Vascular system; Case-Control Studies; Coronary heart disease; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; Genotype; Georgia - epidemiology; Heart; Humans; Male; Medical sciences; Middle Aged; Myocardial infarction; Myocardial Infarction - ethnology; Myocardial Infarction - genetics; Odds Ratio; PAI-1; Plasminogen Activator Inhibitor 1 - genetics; Polymorphism, Genetic; Promoter Regions, Genetic - genetics; Risk; t-PA; Tissue Plasminogen Activator - genetics; Venous thromboembolism; Venous Thrombosis - ethnology; Venous Thrombosis - genetics; Georgia; Myocardial infarction; PAI-1; African-Americans; genetics; Venous thromboembolism; t-PA; Human; Serine endopeptidases; Infarct; Enzyme; Pathogenesis; Cardiovascular disease; Genotype; Coronary heart disease; Myocardial disease; Genetic determinism; Thrombosis; t-Plasminogen activator; Venous disease; Vascular disease; Peptidases; Plasminogen activator inhibitor 1; Myocardium; Hydrolases; Black American; Thromboembolism; Vein; Polymorphism
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/S0049-3848(00)00236-X

To determine whether or not the PAI-1 4G/5G and t-PA I/D polymorphisms in African-Americans were linked to cardiovascular disease, the association of these polymorphisms to disease expression was analyzed in a recently completed case-control study of myocardial infarction or venous thromboembolism among African-Americans. All African-Americans patients with a history of venous thromboembolism attending an anticoagulant clinic, and patients with a history of a MI attending a cardiology clinic at a large local urban public hospital were eligible for inclusion as cases in the study. In this study it was observed that there was a statistically significant association between the D allele of the t-PA I/D polymorphism and venous thromboembolism and a nonsignificant association between the D allele and myocardial infarction among African-Americans. t-PA antigen levels were statistically significantly higher among both myocardial infarction and venous thromboembolism cases compared with control subjects. The genotypes were unrelated to t-PA plasma levels. There was no association between either myocardial infarction or venous thromboembolism and the 4G/5G PAI-1 genotype. It was also found that genotype frequencies for both PAI-1 4G/5G and t-PA I/D polymorphisms in African-American adults were different from those reported for both U.S. Causcians and Europeans.