Omicron variant (B.1.1.529) of SARS-CoV-2: Mutation, infectivity, transmission, and vaccine resistance

Omicron variant (B.1.1.529) of SARS-CoV-2: Mutation, infectivity, transmission, and vaccine resistance

The appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant Omicron (B.1.1.529) has caused panic responses around the world because of its high transmission rate and number of mutations. This review summarizes the highly mutated regions, the essential infectivity, transmis...

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Bibliographic Details
Published in:World journal of clinical cases Vol. 10; no. 1; pp. 1 - 11
Main Authors: Ren, Shi-Yan, Wang, Wen-Biao, Gao, Rong-Ding, Zhou, Ai-Mei
Format: Journal Article
Language:English
Published: United States Baishideng Publishing Group Inc 07-01-2022
Subjects:
Minireviews
COVID-19
SARS-CoV-2
Omicron variant B.1.1.529
Genotyping
Infectivity
RT-PCR
Transmission
Variant of concern
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Summary:The appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant Omicron (B.1.1.529) has caused panic responses around the world because of its high transmission rate and number of mutations. This review summarizes the highly mutated regions, the essential infectivity, transmission, vaccine breakthrough and antibody resistance of the Omicron variant of SARS-CoV-2. The Omicron is highly transmissible and is spreading faster than any previous variant, but may cause less severe symptoms than previous variants. The Omicron is able to escape the immune system's defenses and coronavirus disease 2019 vaccines are less effective against the Omicron variant. Early careful preventive steps including vaccination will always be key for the suppression of the Omicron variant.
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SourceType-Scholarly Journals-1
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Corresponding author: Shi-Yan Ren, MD, PhD, Chief Doctor, Surgeon, Laser Vascular Surgery, Aviation General Hospital, China Medical University, No. 2 Beiyuan Road, Chaoyang District, Beijing 10012, China. rens66@126.com
Author contributions: Ren SY searched the references, designed, composed, revised and submitted the manuscript; Wang WB, Gao RD, and Zhou AM searched the references, designed and discussed the manuscript.
ISSN:2307-8960
2307-8960
DOI:10.12998/wjcc.v10.i1.1