The antitumor activity of naturally occurring chromones: A review

• Published in: Fitoterapia Vol. 135; pp. 114 - 129
• Main Authors: Duan, Ya-di, Jiang, Yan-yan, Guo, Feng-xia, Chen, Lu-xiao, Xu, Lu-lu, Zhang, Wei, Liu, Bin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-06-2019; Elsevier Science Ltd
• Subjects: Angiogenesis Inhibitors - chemistry; Angiogenesis Inhibitors - pharmacology; Anticancer properties; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antioxidants; Antitumor activity; Cell Survival - drug effects; Chemoprevention; Chemotherapy; Chromone; Chromones - classification; Chromones - pharmacology; Cytotoxicity; Immunomodulation - drug effects; Immunoregulation; Inflammation; Mechanism; Molecular Structure; Neoplasm Metastasis - drug therapy; Toxicity; NB4; PSN-1; BGC-823; L5178Y; LNCaP; H-1975; Cytotoxicity; P-388; SW-620; MTT; CMC-9209; Bx-PC-3; Chromone; IC50; EC50; K-562; U-255; T-47D; SV-HUC; QR; Mia Paca-2; Panc-1; U-937; SNB-75; NCI-H187; VEGF-A; Med; NCI-H226; LD50; HT-29; H4IIE; HL-60; UM-UC14; P9-WT; SHSY5Y; BC; THP-1; RWPE-1; SRB; Molt-3; Molt-4; SF-295; SGC-7901; MCF-7; A-549; HCT-116; MS1; PARP; AsPC-1; SKOV-3; SCID; Mechanism; HS578T; SMMC-7721; HeLa; HT-1080; mEH; C6; ID50; KB; ED50; BEL-7402; GI50; HaCat; Kato-3; A-549/Taxol; H-460; SK-OV-3; MDA-MB-468; MK-1; Huh-7; GST; A-375; SF-539; A-2780; B16-F10; Antitumor activity; DU-145; Hep-G2; Jurkat; PC-3; MDA-MB-231
• ISSN: 0367-326X; 1873-6971
• DOI: 10.1016/j.fitote.2019.04.012

Chromones are a group of compounds widely distributed in nature with wide range of biological activities, including antitumor, antimicrobial, antiviral, anti-inflammatory, antioxidant, and so on. This review mainly summarizes chromones with antitumor activity in nature and classifies them into three groups, including chromanones, simple chromones, and fused chromones. They exhibit antitumor activity through broad range of mechanisms including cytotoxicity, antimetastasis, antiangiogenesis, chemoprevention, immune regulation, etc.
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