Development of new drug delivery system for protein drugs using silicone (I)

A novel technique, by which protein drugs effective in small doses can be released over a long period, was developed using silicone and a water-soluble substance. In this study, interferon (IFN) was used as a model of the protein drugs. The IFN–silicone formulation released IFN over long periods of...

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Bibliographic Details
Published in:	Journal of controlled release Vol. 66; no. 1; pp. 49 - 61
Main Authors:	Kajihara, Masako, Sugie, Toshihiko, Mizuno, Masayuki, Tamura, Nobuhiko, Sano, Akihiko, Fujioka, Keiji, Kashiwazaki, Yasuo, Yamaoka, Takashi, Sugawara, Shuichi, Urabe, Yosuke
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 03-05-2000 Elsevier
Subjects:	Animals Antineoplastic agents Antitumor activity Biological and medical sciences Chemotherapy Delayed-Action Preparations Dimethylpolysiloxanes Female General pharmacology Glycine - chemistry Interferon-alpha - administration & dosage Interferon-alpha - pharmacokinetics Interferon-alpha - therapeutic use Kinetics Long-acting delivery Medical sciences Mice Mice, Nude Microscopy, Confocal Neoplasm Transplantation Osmotic Pressure Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Powders Protein delivery Silicone Silicones - chemistry Solubility Tumor Cells, Cultured Water-soluble additive Water-soluble additive Protein delivery Antitumor activity Long-acting delivery Silicone Antineoplastic agent Encapsulation Slow release form Drug carrier Blood Blood plasma Formulation Subcutaneous administration Siloxane polymer Release Pharmaceutical technology Control release polymer Rodentia Cytokine Malignant tumor In vitro Protein In vivo Vertebrata Chemotherapy Mammalia Treatment Mouse Animal Dosage form Active ingredient Interferon Pharmacokinetics Physicochemical properties
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