Development of new drug delivery system for protein drugs using silicone (I)

• Published in: Journal of controlled release Vol. 66; no. 1; pp. 49 - 61
• Main Authors: Kajihara, Masako, Sugie, Toshihiko, Mizuno, Masayuki, Tamura, Nobuhiko, Sano, Akihiko, Fujioka, Keiji, Kashiwazaki, Yasuo, Yamaoka, Takashi, Sugawara, Shuichi, Urabe, Yosuke
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 03-05-2000; Elsevier
• Subjects: Animals; Antineoplastic agents; Antitumor activity; Biological and medical sciences; Chemotherapy; Delayed-Action Preparations; Dimethylpolysiloxanes; Female; General pharmacology; Glycine - chemistry; Interferon-alpha - administration & dosage; Interferon-alpha - pharmacokinetics; Interferon-alpha - therapeutic use; Kinetics; Long-acting delivery; Medical sciences; Mice; Mice, Nude; Microscopy, Confocal; Neoplasm Transplantation; Osmotic Pressure; Particle Size; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Powders; Protein delivery; Silicone; Silicones - chemistry; Solubility; Tumor Cells, Cultured; Water-soluble additive; Water-soluble additive; Protein delivery; Antitumor activity; Long-acting delivery; Silicone; Antineoplastic agent; Encapsulation; Slow release form; Drug carrier; Blood; Blood plasma; Formulation; Subcutaneous administration; Siloxane polymer; Release; Pharmaceutical technology; Control release polymer; Rodentia; Cytokine; Malignant tumor; In vitro; Protein; In vivo; Vertebrata; Chemotherapy; Mammalia; Treatment; Mouse; Animal; Dosage form; Active ingredient; Interferon; Pharmacokinetics; Physicochemical properties
• ISSN: 0168-3659; 1873-4995
• DOI: 10.1016/S0168-3659(99)00257-6

A novel technique, by which protein drugs effective in small doses can be released over a long period, was developed using silicone and a water-soluble substance. In this study, interferon (IFN) was used as a model of the protein drugs. The IFN–silicone formulation released IFN over long periods of time in vitro and suppressed tumor growth in nude mice for about 100 days after a single administration. This indicates that physiologically active IFN is released over a prolonged period of time from the IFN–silicone formulation in vivo. Silicone formulations are expected to be a practically feasible sustained-release formulation.