Failure of dietary lyophilized strawberries to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-and benzo[ a]pyrene-induced lung tumorigenesis in strain A/J mice

• Published in: Cancer letters Vol. 159; no. 2; pp. 113 - 117
• Main Authors: Carlton, Peter S., Kresty, Laura A., Stoner, Gary D.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 31-10-2000; Elsevier
• Subjects: 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone; Adenoma - chemically induced; Adenoma - prevention & control; Animals; Antineoplastic Agents - pharmacology; Benzo(a)pyrene - toxicity; Benzo[ a]pyrene; Biological and medical sciences; Biological Assay; Carcinogenesis, carcinogens and anticarcinogens; Carcinogens - toxicity; Chemoprevention; Diet; Foods and miscellaneous; Freeze Drying; Fruit; Lung; Lung Neoplasms - chemically induced; Lung Neoplasms - prevention & control; Medical sciences; Mice; Mice, Inbred Strains; Mouse; Nitrosamines - toxicity; Strawberries; Tumors; Benzo[ a]pyrene; Strawberries; Mouse; Lung; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone; Chemoprevention; Cell proliferation; Lung disease; Freeze drying; Respiratory disease; Rodentia; Oral administration; Supplemented diet; Malignant tumor; Carcinogenesis; Bronchopulmonary; Prevention; Carcinogen; Vertebrata; Mammalia; Animal; Strawberry; Bronchus disease
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/S0304-3835(00)00464-X

In the present study, we examined the ability of lyophilized strawberries in the diet to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)- and benzo[
a]pyrene (B[
a]P)-induced lung tumorigenesis in the A/J mouse. Groups of 20 mice were administered purified AIN-76A diet containing 10% lyophilized strawberries 1 week before carcinogen dosing, and for the duration of the study. NNK was administered by i.p. injection in five, 0.414 mg doses. B[
a]P was administered by gavage in five, 0.2 mg doses. At 20 weeks, there were no significant differences in tumor incidence or tumor multiplicity between the NNK+10% lyophilized strawberry group and the NNK control group. Similarly, at 24 weeks, there were no differences in tumorigenesis between the B[
a]P+10% lyophilized strawberry group and the B[
a]P control group. Therefore, lyophilized strawberries at 10% in the diet failed to inhibit NNK- and B[
a]P-induced mouse lung tumorigenesis.