The Study of Relationship between Serum Levels of Soluble fms-like Tyrosine Kinase-1 and Soluble Fibrinogen-like Protein 2 with Delayed Graft Function after Kidney Transplantation

• Published in: Iranian journal of allergy, asthma, and immunology Vol. 18; no. 4; p. 412
• Main Authors: Akbari, Hossein, Hooshyar, Zahra, Shabanitabar, Saeede, Salmani, Ali, Nikoueinejad, Hassan, Einollahi, Behzad
• Format: Journal Article
• Language: English
• Published: Iran Tehran University of Medical Sciences 17-08-2019
• Subjects: Adult; Biomarkers; Delayed graft function; Delayed Graft Function - blood; Delayed Graft Function - immunology; Dialysis; Enzyme-linked immunosorbent assay; Female; Fgl2 protein; Fibrinogen; Graft Rejection; Graft Survival - immunology; HLA Antigens - genetics; HLA Antigens - immunology; Humans; Immunomodulation; Kidney Transplantation; Kidney transplants; Male; Middle Aged; Plasma levels; Protein-tyrosine kinase; Retrospective Studies; ROC Curve; Serum levels; Soluble fibrinogen-like protein 2; Soluble VEGF receptor-1; Transplants & implants; Vascular Endothelial Growth Factor Receptor-1 - blood; Young Adult; Soluble fibrinogen-like protein 2; Soluble VEGF receptor-1; Delayed graft function; Kidney transplantation
• ISSN: 1735-1502; 1735-5249
• DOI: 10.18502/ijaai.v18i4.1419

Delayed graft function (DGF) is a transplant complication which means a need to dialysis throughout the first week after transplantation. This study aimed to ascertain the relationship between the two immunomodulatory factors of soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble fibrinogen-like protein 2 (sFGL-2) with DGF after transplantation. This case-control study was done in 2 groups of 58 kidney transplant patients with and without DGF. The control group included the patients who didn't show DGF symptoms. Then, serum levels of sFlt-1and sFGL-2 in all blood samples were measured by ELISA. Serum sFlt-1 and sFGL-2 levels were significantly higher in the DGF group compared to those in the control group (p≤0.001). sFlt-1 and sFGL-2 serum levels significantly affect DGF (p<0.001) in such a way that they may be diagnostic factors of DGF. This study showed a significant relationship between sFlt-1 as well as sFGL-2 and DGF. Therefore, plasma levels of sFlt-1 and sFGL-2 may be used as diagnostic tools to determine the risk of DGF.