Identification and Follow-up of COVID-19 Related Matching Ventilation and Perfusion Defects on Functional Imaging Using VQ SPECT/CT

• Published in: Nuclear medicine and molecular imaging Vol. 57; no. 1; pp. 9 - 15
• Main Authors: Evbuomwan, Osayande, Endres, Walter, Tebeila, Tebatso, Engelbrecht, Gerrit
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01-02-2023; Springer Nature B.V; 대한핵의학회
• Subjects: Abnormalities; Cardiology; Computed tomography; Coronaviruses; COVID-19; Defects; Emission analysis; Imaging; Matching; Medicine; Medicine & Public Health; Nuclear Medicine; Oncology; Original; Original Article; Orthopedics; Photon emission; Radiology; Tomography; Ventilation; Viral diseases; 방사선과학; COVID-19; VQ SPECT/CT; Pulmonary microthrombosis; Small airway disease; Mosaic hypoattenuation
• ISSN: 1869-3474; 1869-3482
• DOI: 10.1007/s13139-022-00776-0

Purpose
Available clinical data have revealed that coronavirus disease 2019 (COVID-19) is associated with a risk of pulmonary microthrombosis and small airway disease. These patients present with varying degrees of perfusion abnormalities. The purpose of this study was to evaluate the use of a ventilation/perfusion single-photon emission computed tomography/computed tomography (VQ SPECT/CT) in the detection and follow-up of persistent lung perfusion abnormalities that were suspected to be due to pulmonary microthrombosis, small airway disease, or both.
Methods
A retrospective study was conducted at the department of nuclear medicine of Universitas Academic Hospital in Bloemfontein, South Africa. We reviewed the studies of 78 non-hospitalized patients with COVID-19 infection referred to our department from July 2020 to June 2021 for a perfusion only SPECT/CT study or a VQ SPECT/CT study. Pulmonary embolism was suspected in all 78 cases.
Results
Seventy-eight patients were studied. The median (interquartile range) age was 45 (41–58) years, and the majority (
n
 = 69; 88.5%) were females. Twenty-two (28.2%) of these patients had matching VQ defects with mosaic attenuation on CT. All nine of the patients who had follow-up studies had these abnormalities persistently, even after 1 year.
Conclusion
We confirm that the VQ scan is a safe and effective tool to identify and follow-up recovered COVID-19 patients with persistent ventilation and perfusion abnormalities suspicious of small airway disease and pulmonary microthrombosis.