Inclusion complex of fenbufen with β-cyclodextrin

An inclusion complex of fenbufen with β‐cyclodextrin (β‐CD) in aqueous solution was characterized by 1H‐NMR spectroscopy. The [1:1] stoichiometry was determined and a stability constant of several 1000s (M−1) was calculated. The geometry of the inclusion complex was established based on MM+ molecula...

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Bibliographic Details
Published in:	Biopolymers Vol. 73; no. 4; pp. 451 - 456
Main Authors:	Bratu, I., Gavira-Vallejo, J. M., Hernanz, A., Bogdan, M., Bora, Gh
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-03-2004
Subjects:	1H-NMR antiinflammatory drugs beta-Cyclodextrins Cyclodextrins - chemistry Drug Combinations Drug Stability fenbufen Hypoglycemic Agents - chemistry inclusion complexes Magnetic Resonance Spectroscopy Models, Molecular molecular modeling Molecular Structure Phenylbutyrates - chemistry Solutions stability constant stoichiometry Thermodynamics Water - chemistry β-cyclodextrin
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Summary:	An inclusion complex of fenbufen with β‐cyclodextrin (β‐CD) in aqueous solution was characterized by 1H‐NMR spectroscopy. The [1:1] stoichiometry was determined and a stability constant of several 1000s (M−1) was calculated. The geometry of the inclusion complex was established based on MM+ molecular mechanics calculations. © 2004 Wiley Periodicals, Inc. Biopolymers, 2004
Bibliography:	istex:C5DFDAB2444EFE527C25547654701140DCCAF2D1 ArticleID:BIP10555 NATO Scientific Committee(to I.B.) ark:/67375/WNG-WV7NMS0J-T ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0006-3525 1097-0282
DOI:	10.1002/bip.10555