A comparative study of vestibular projection connectivity and balance in healthy young adults and elderly subjects

• Published in: BMC neurology Vol. 24; no. 1; pp. 324 - 9
• Main Authors: Yeo, Sang Seok, Oh, Seunghue, Cho, In Hee
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06-09-2024; BioMed Central; BMC
• Subjects: Adult; Age; Aged; Aging; Aging - physiology; Balance; Brain; Brain stem; Cerebral cortex; Comparative analysis; Connectivity; Dentate nucleus; Diffusion tensor imaging; Diffusion Tensor Imaging - methods; Female; Geriatrics; Health aspects; Humans; Magnetic resonance imaging; Male; Measurement techniques; Medical examination; Middle Aged; Musculoskeletal diseases; Neural circuitry; Neural networks; Neural Pathways - diagnostic imaging; Neuroimaging; Physiological aspects; Postural Balance - physiology; Somatosensory cortex; Ventralis intermedius; Vestibular apparatus; Vestibular nuclei; Vestibular Nuclei - diagnostic imaging; Vestibular Nuclei - physiology; Vestibular nucleus; Vestibular system; Vestibule, Labyrinth - diagnostic imaging; Vestibule, Labyrinth - physiology; Young Adult; Young adults; South Korea; Ventralis intermedius; Aging; Connectivity; Vestibular nucleus; Diffusion tensor imaging
• ISSN: 1471-2377; 1471-2377
• DOI: 10.1186/s12883-024-03819-5

Vestibular function is controlled by interactions between various neuropathways that have different effects on balance and are connected to various brain areas. However, few studies have investigated the relation between changes in VN connectivity and aging using neuroimaging. We investigated neural connectivities in the vestibular nucleus (VN) and ventralis intermedius (VIM) nucleus of the thalamus in young and old healthy adults by diffusion tensor imaging.
This study recruited twenty-three normal healthy adults with no history of a neurological or musculoskeletal disease, that is, eleven old healthy adults (6 males, 5 females; mean age 63.36 ± 4.25 years) and 12 young healthy adults (7 males, 5 females; mean age 28.42 ± 4.40 years). Connectivity was defined as the incidence of connection between the VN, VIM, and target brain regions. Incidence of connection was counted from VN and VIM to each brain region. The subjective visual vertical (SVV) and the Berg balance scale (BBS) were used to assess vestibular function and balance.
The VN showed high connectivity with brainstem (dentate nucleus, medial longitudinal fasciculus, and VIM), but relatively low connectivity with cerebral cortex (parieto-insular vestibular cortex (PIVC) and primary somatosensory cortex) at a threshold of 30 streamlines. In particular, VN connectivity with PIVC was significantly lower in elderly adults (> 60 years old) than in young adults (20-40 years old) (p < 0.05). VIM showed high to mid connectivity with brainstems and cerebral cortexes at a threshold of 30, but no significant difference was observed between young and old adults (p > 0.05). SVV and BBS showed no significant differences between young and old adults (p > 0.05).
We investigated incidences of neural connectivities of VN and VIM in young and old healthy adults. Our results provide basic data that might be clinically useful following injury of vestibular-related areas.