Transient Neonatal Diabetes Mellitus with an Unknown Cause in a 1-Month-Old Infant: A Case Report

• Published in: Healthcare (Basel) Vol. 12; no. 13; p. 1257
• Main Authors: Tarasiewicz, Mateusz, Pietrzykowska, Anna, Włodarczyk, Julia, Seget, Sebastian, Gadzalska, Karolina, Jakiel, Paulina, Skoczylas, Sebastian, Jarosz-Chobot, Przemysława, Borowiec, Maciej
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-07-2024
• Subjects: Abdomen; Age; Antibodies; Blood sugar monitoring; Care and treatment; Case reports; Children & youth; continuous glucose monitoring; Development and progression; Dextrose; Gene mutations; Genetic aspects; Genetic screening; Genetic testing; Gestational diabetes; Glucose; Glucose monitoring; Health aspects; Hemoglobin; Hyperglycemia; Infants (Newborn); Insulin; Insulin lispro; insulin therapy; Intensive care; monogenic diabetes; Mutation; next-generation sequencing; Pediatrics; transient neonatal diabetes mellitus; Type 2 diabetes; Ultrasonic imaging; monogenic diabetes; continuous glucose monitoring; insulin therapy; next-generation sequencing; transient neonatal diabetes mellitus
• ISSN: 2227-9032; 2227-9032
• DOI: 10.3390/healthcare12131257

Transient neonatal diabetes mellitus (TNDM) is a genetically heterogeneous form of neonatal diabetes characterized by hyperglycemia that remits during infancy with a tendency to recur in later life. This case report presents the history of a male infant with transient neonatal diabetes mellitus. The patient was treated with a continuous subcutaneous insulin infusion (CSII) and a continuous glucose monitoring (CGM) system until the age of 2 months, when the normoglycemia connected with a withdrawal of treatment was noted. The genetic test results excluded the majority of known mutations related to TNDM. This case report focuses on various genetic mutations and the clinical features connected with them that cause TNDM and highlights the difficulties in the diagnostic and therapeutic processes of this disease. CSII and CGM systems seem to be a safe and effective treatment option in TNDM and may be used in the therapy.