Pelvic exenteration for locally advanced rectal carcinoma: Factors predicting improved survival

• Published in: Surgery Vol. 121; no. 5; pp. 479 - 487
• Main Authors: Meterissian, Sarkis H, Skibber, John M, Giacco, Geoffrey G, El-Naggar, Adel K, Hess, Kenneth R, Rich, Tyvin A
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01-05-1997; Elsevier
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Adenocarcinoma - therapy; Biological and medical sciences; Combined Modality Therapy; Female; Humans; Male; Medical sciences; Middle Aged; Multivariate Analysis; Pelvic Exenteration; Ploidies; Predictive Value of Tests; Prognosis; Rectal Neoplasms - genetics; Rectal Neoplasms - mortality; Rectal Neoplasms - pathology; Rectal Neoplasms - surgery; Rectal Neoplasms - therapy; Retrospective Studies; Stomach, duodenum, intestine, rectum, anus; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Survival Rate; Human; Ploidy; Rectal disease; Carcinoma; Surgical resection; Malignant tumor; Statistical study; Survival; Extension; Treatment; Surgery; DNA; Rectum; Predictive value; Digestive diseases; Intestinal disease; Evolution; Combined treatment; Age
• ISSN: 0039-6060; 1532-7361
• DOI: 10.1016/S0039-6060(97)90100-8

Background. The purpose of this retrospective review was to determine whether a number of clinicopathologic factors (age, gender, type of exenteration, tumor extent, adjuvant therapy, tumor DNA ploidy, and S-phase fraction) that could be determined before operation were useful in predicting survival in patients undergoing pelvic exenteration for rectal cancer.
Methods. Between 1983 and 1992, 40 patients (15 male and 25 female) at our institution underwent pelvic exenteration for rectal adenocarcinoma in which tumor-free pathologic margins were obtained. Twenty-nine patients presented with primary tumors; 11 had recurrent disease. A total exenteration was performed in 20 patients, posterior exenteration in 18 patients, and an anterior exenteration in 2 patients.
Results. By multivariate (Cox proportional hazards regression) analysis, age, preoperative chemoradiation therapy, and an S phase of 10% or greater were found to be significant predictors of survival. Age older than 55 years was associated with a relative risk for cancer-related death (RR) of 0.13 (p = 0.02), and chemoradiation had an RR of 0.05 (p = 0.01), indicating their beneficial effect. An S-phase fraction of 10% or greater had an RR of 16.97 (p = 0.03), indicating a poor survival. The clinicopathologic factors listed above were used to derive a prognostic index (PI). A PI of less than 1.37 was associated with a 5-year survival rate of 65% (low risk), whereas patients with a PI of 1.37 or greater had a 5-year survival rate of 20% (high risk) (p = 0.005).
Conclusions. These results indicate that adjuvant chemoradiation may significantly improve survival in patients who require pelvic exenteration for resection of locally advanced rectal carcinoma. An S-phase fraction of 10% or greater is also predictive of a poor outcome. Use of these factors allowed the sgeneration of a PI that identifies high- and low-risk patients. Consideration of the ability to deliver chemoradiation and the determinates of the tumor S-phase fraction in patients requiring pelvic exenteration for rectal cancer may be helpful in predicting outcome and planning therapy.