Silent myocardial ischemia during daily activities in asymptomatic men with positive exercise test responses

• Published in: The American journal of cardiology Vol. 59; no. 1; pp. 45 - 49
• Main Authors: Coy, Kevin M., Imperi, Greg A., Lambert, Charles R., Pepine, Carl J.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 1987; Elsevier
• Subjects: Activities of Daily Living; Adult; Aged; Ambulatory Care; Angiography; Biological and medical sciences; Cardiology. Vascular system; Coronary Disease - diagnostic imaging; Coronary Disease - physiopathology; Coronary heart disease; Electrocardiography; Exercise Test; Heart; Humans; Male; Medical sciences; Middle Aged; Monitoring, Physiologic - methods; Human; Electrodiagnosis; Electrocardiography; Cardiovascular disease; Exercise tolerance test; Asymptomatic; Ambulatory; Coronary heart disease; Monitoring
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/S0002-9149(87)80066-8

The usefulness of prolonged ambulatory electrocardiographic monitoring (AEM) for detecting ischemia was investigated in 17 asymptomatic men who had ischemic-type ST-segment depression (≥2.0 mm) during treadmill exercise testing. No patient took anti-ischemic medications and all patients underwent coronary angiography. A total of 1,154 hours (range 64 to 72 hours/patient) of high-quality AEM recordings was obtained. Silent ischemia (episodes of asymptomatic ischemic-type ST depression of 60 seconds or longer) occurred in 11 patients during daily activity detected by AEM. In 6 other patients, no myocardial ischemic episodes were found. But 1 of these patients withdrew after only 24 hours of AEM and the remaining 5 had no significant coronary artery disease (CAD). All 11 patients who had silent ischemia had significant CAD (at least 50% stenosis) on angiography. There was wide intrapatient variability in the frequency of silent ischemic episodes. Silent ischemia was identified in 6 of these 11 patients after 24 hours of AEM, in 2 after 48 hours and in 3 after 72 hours. Thus, asymptomatic men with positive exercise test responses and CAD have silent ischemic episodes during daily activity. AEM may be useful in helping to predict which patients with asymptomatic positive exercise test responses have CAD; however, extended AEM periods are required.