Synthesis and characterization of silane coated magnetic nanoparticles/glycidylmethacrylate-grafted-maleated cyclodextrin composite hydrogel as a drug carrier for the controlled delivery of 5-fluorouracil

• Published in: Materials Science & Engineering C Vol. 55; pp. 471 - 481
• Main Authors: Anirudhan, Thayyath.S., Divya, Peethambaran.L., Nima, Jayachandran
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-10-2015
• Subjects: 5-Fluorouracil; Antimetabolites, Antineoplastic - administration & dosage; Bacteria; Coated Materials, Biocompatible; Computational efficiency; Computing time; Controlled drug delivery; Cyclodextrin; Cyclodextrins; Cyclodextrins - chemistry; Cytotoxicity; Diffusion; Drug Carriers; Drug delivery systems; Drugs; Fluorouracil - administration & dosage; Graft polymers; Hydrogels; Magnetic nanoparticles; Magnetics; Methacrylates - chemistry; Microscopy, Electron, Transmission; Nanoparticles; Silanes - chemistry; 5-Fluorouracil; Ms; FT-IR; Cytotoxicity; DLS; XRD; MTT assay; MNP; DMEM; DDS; Controlled drug delivery; MPTMS; MACD; GMA; EGDMA; DMF; Graft polymers; EE; PBS; Magnetic nanoparticles; AIBN; β-CD; Cyclodextrin; MAH; FCS; SEM; DLE; 5-FU
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2015.05.068

A novel drug delivery system (DDS), 3-methacryloxypropyl trimethoxy silane coated magnetic nanoparticles polymerized with glycidylmethacrylate-grafted-maleated cyclodextrin (MPTMS-MNP-poly-(GMA-g-MACD)) was prepared in the presence of ethyleneglycoldimethacrylate as cross-linker and a,aʹ-azobisisobutyronitrile as initiator and characterized by means of SEM, FT-IR, XRD, DLS, VSM and TEM. The encapsulation efficiency (EE) and drug loading efficiency (DLE) of the DDS were tested using various formulations of DDS. The DDS showed activity against gram positive and negative bacteria. The cytotoxicity studies were also performed using MCF-7 (human breast carcinoma) cells and found that the drug carrier is biocompatible and it shows sustained and controlled release of drug to the targeted site. The drug release mechanism was found to obey non-Fickian diffusion (n=0.709) method where polymer relaxation and drug diffusion played important roles in drug release. In this DDS, advantages of core magnetic nanoparticles and host–guest interactions of β-CD were combined for the controlled delivery of 5-Fluorouracil (5-FU) to maintain the therapeutic index of the drug.
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•Novel drug delivery system MPTMS-MNP-poly-(GMA-g-MACD) was prepared and characterized.•Presence of magnetic core enables the controlled delivery of anticancer drug 5-fluorouracil.•Grafting of MAH and GMA increases the bio-compatibility of material.•The presence of GMA and COOH groups converts the polymer into a hydrogel.•Drug release and cytotoxicity studies were conducted.