The fundamental theorem of neutral evolution: rates of substitution and mutation should factor in premeiotic clusters

The fundamental theorem of neutral evolution: rates of substitution and mutation should factor in premeiotic clusters

Mutations do not always arise as single events. Many new mutations actually occur in the cell lineage before germ cell formation or meiosis and are therefore replicated pre-meiotically. The increased likelihood of substitutions caused by these clusters of new mutant alleles can change the fundamenta...

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Bibliographic Details
Published in:Genetica Vol. 125; no. 2-3; pp. 333 - 339
Main Authors: Woodruff, R C, Thomson, J N
Format: Journal Article
Language:English
Published: Netherlands Springer Nature B.V 01-11-2005
Subjects:
Alleles
Animals
Calculus
Cell lineage
Evolution, Molecular
Humans
Meiosis - genetics
Models, Genetic
Multigene Family
Mutation
Studies
Online Access:Get full text
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Summary:Mutations do not always arise as single events. Many new mutations actually occur in the cell lineage before germ cell formation or meiosis and are therefore replicated pre-meiotically. The increased likelihood of substitutions caused by these clusters of new mutant alleles can change the fundamental theorem of neutral evolution.
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ISSN:0016-6707
1573-6857
DOI:10.1007/s10709-005-4982-7