Linkage relations of dumpy, a recessive mutant on chromosome 13 of the mouse

A mutant characterized by small size, short snout, short middle and inner metatarsals and hallux, low vigor, and poor reproduction appeared in F2 from a cross of BALB/c in 1965. It proved recessive and was named dumpy, with symbol dpy. After some 10 years of maintenance, the stock showed much improv...

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Bibliographic Details
Published in:	The Journal of heredity Vol. 72; no. 5; p. 358
Main Author:	Hollander, W F
Format:	Journal Article
Language:	English
Published:	United States 01-09-1981
Subjects:	Animals Bone Diseases, Developmental - genetics Chromosome Mapping Crosses, Genetic Crossing Over, Genetic Genes, Recessive Genetic Linkage Mice Mice, Mutant Strains - genetics Mutation Sex Factors
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Summary:	A mutant characterized by small size, short snout, short middle and inner metatarsals and hallux, low vigor, and poor reproduction appeared in F2 from a cross of BALB/c in 1965. It proved recessive and was named dumpy, with symbol dpy. After some 10 years of maintenance, the stock showed much improved vigor and reproduction, but it is not carried on a pure-strain background. Linkage was found with satin (sa) in linkage group XIV, chromosome 13. Data from female heterozygotes gave about 16 percent crossing over, and from males about 10 percent. Three-point tests involving XtJ showed the map order XtJ-sa-dpy, again with sex difference in crossing over, confirming results of studies by others for this region of chromosome 13.
ISSN:	0022-1503
DOI:	10.1093/oxfordjournals.jhered.a109526