Complement in inflammation: induction of nephritides and progress to chronicity

The C5b-9 complex has a dual role as a factor involved in the initiation of nephritides and in the progress to chronicity and sclerosis. The unique pathophysiology of the membrane attack complex, distinct from other mediators, is its independence from specific receptors. It inserted in any membrane...

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Bibliographic Details
Published in:	International archives of allergy and applied immunology Vol. 94; no. 1-4; p. 23
Main Authors:	Rother, K, Hänsch, G M, Rauterberg, E W
Format:	Journal Article
Language:	English
Published:	Switzerland 01-01-1991
Subjects:	Animals Chronic Disease Complement Membrane Attack Complex - physiology Feedback Glomerulosclerosis, Focal Segmental - etiology Humans Kidney Glomerulus - immunology Nephritis - etiology
Online Access:	Get more information
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Summary:	The C5b-9 complex has a dual role as a factor involved in the initiation of nephritides and in the progress to chronicity and sclerosis. The unique pathophysiology of the membrane attack complex, distinct from other mediators, is its independence from specific receptors. It inserted in any membrane lipid bilayer tested so far.
ISSN:	0020-5915
DOI:	10.1159/000235320