Partial androgen insensitivity--are all tissues equal?

Nonaromatizable androgens, administered in high doses to an adult patient with partial androgen insensitivity, failed to result in a change in phallic size despite a clear decline in SHBG and gonadotropin levels. These findings raise the question of differential tissue sensitivity to androgens. Beca...

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Bibliographic Details
Published in:	Fertility and sterility Vol. 60; no. 2; p. 366
Main Authors:	Keely, E J, Belsham, D D, Wrogemann, K, Faiman, C
Format:	Journal Article
Language:	English
Published:	United States 01-08-1993
Subjects:	Adult Androgens - pharmacology Binding, Competitive Drug Resistance Fibroblasts - metabolism Genitalia, Male - metabolism Genitalia, Male - pathology Gonadotropins - blood Humans Male Penis - abnormalities Receptors, Androgen - metabolism Reference Values Sex Hormone-Binding Globulin - analysis Skin - metabolism Skin - pathology
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Summary:	Nonaromatizable androgens, administered in high doses to an adult patient with partial androgen insensitivity, failed to result in a change in phallic size despite a clear decline in SHBG and gonadotropin levels. These findings raise the question of differential tissue sensitivity to androgens. Because ancillary laboratory testing does not predict reliably the genital response, a therapeutic trial should be advocated in such cases.
ISSN:	0015-0282
DOI:	10.1016/S0015-0282(16)56114-7