Truncus arteriosus: ten-year experience with homograft repair in neonates and infants

• Published in: The Annals of thoracic surgery Vol. 66; no. 6; pp. S183 - S188
• Main Authors: Urban, Andreas E, Sinzobahamvya, Nicodeme, Brecher, Anne Marie, Wetter, Jutta, Malorny, Stephan
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01-12-1998; Elsevier Science
• Subjects: Actuarial Analysis; Aorta, Thoracic - abnormalities; Aortic Valve - transplantation; Biological and medical sciences; Cardiology. Vascular system; Child; Child, Preschool; Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava; Coronary Vessel Anomalies - complications; Evaluation Studies as Topic; Follow-Up Studies; Heart; Heart Ventricles - abnormalities; Heart Ventricles - surgery; Hospital Mortality; Humans; Infant; Infant, Newborn; Longitudinal Studies; Medical sciences; Pulmonary Artery - abnormalities; Pulmonary Artery - surgery; Pulmonary Valve - transplantation; Pulmonary Valve Insufficiency - surgery; Reoperation; Risk Factors; Survival Rate; Transplantation, Homologous; Truncus Arteriosus, Persistent - surgery; Human; Reconstruction; Right ventricle; Cardiovascular disease; Transplantation; Homotransplantation; Congenital disease; Pulmonary valve; Result; Vascular disease; Treatment; Newborn; Heart disease; Surgery; Child; Truncus arteriosus
• ISSN: 0003-4975; 1552-6259
• DOI: 10.1016/S0003-4975(98)01103-5

Background. Early complete repair of truncus arteriosus with homograft reconstruction of the right ventricular outflow tract was performed and long-term results were evaluated.
Methods. Review of 46 consecutive patients with truncus arteriosus who underwent primary correction between June 1987 and May 1997 was performed. Ages ranged from 21 days to 7.2 years (median, 62 days) and weights from 1.8 to 21.5 kg (median, 3.4 kg). Ten patients were operated on before 1 month of age, 20 between 1 and 3 months, 13 between 3 months and 1 year, and 3 at an older age. Associated cardiac conditions were encountered frequently, the most common being coronary artery anomalies (n = 16), truncal valve incompetence (n = 12), and interrupted aortic arch (n = 5). The right ventricular outflow tract was reconstructed with an aortic (n = 28) or a pulmonary homograft (n = 18).
Results. There were two hospital deaths (4.3%). Both patients had severe truncal valve regurgitation and interrupted aortic arch together with other unfavorable conditions. Survival in uncomplicated truncus arteriosus was 100%. Follow-up was from 3 months to 10 years (mean, 36 months). There was one late death 4 months after the initial repair, presumably because of cardiac reason. Actuarial survival was 93% at 4 months and beyond. Actuarial freedom of reoperation in the 27 hospital survivors with aortic homografts was 43% at 75 months; it was 73% at 62 months in the 17 patients surviving with pulmonary homografts.
Conclusions. Neonatal or early infancy complete repair is the treatment with the best potential for survival. The homograft remains our conduit of choice to establish continuity between the right ventricle and the pulmonary artery. Management of severe truncal valve incompetence remains a surgical challenge.