A prospective study of the natural history of large local reactions after Hymenoptera stings in children

Large local reactions are a frequent occurrence after insect stings. We prospectively studied the demography, immunology, and significance of these reactions in the pediatric age group. Most children (83%) who have had large local reactions have positive skin test results to one or more venoms. Elev...

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Bibliographic Details
Published in:	The Journal of pediatrics Vol. 104; no. 5; p. 664
Main Authors:	Graft, D F, Schuberth, K C, Kagey-Sobotka, A, Kwiterovich, K A, Niv, Y, Lichtenstein, L M, Valentine, M D
Format:	Journal Article
Language:	English
Published:	United States 01-05-1984
Subjects:	Adolescent Antibody Formation Bees - immunology Child Child, Preschool Humans Hymenoptera - immunology Hypersensitivity - etiology Hypersensitivity - immunology Immunoglobulin E - immunology Insect Bites and Stings - complications Prospective Studies Radioallergosorbent Test Recurrence Risk Skin Tests Venoms - immunology
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Summary:	Large local reactions are a frequent occurrence after insect stings. We prospectively studied the demography, immunology, and significance of these reactions in the pediatric age group. Most children (83%) who have had large local reactions have positive skin test results to one or more venoms. Elevated amounts of venom-specific IgE antibody are usually present. Over 3 to 5 years, allergic sensitivity declines, as evidenced by less positive skin test results and lower levels of antivenom IgE antibodies. Most significantly, of 113 repeat stings, only 2% resulted in a systemic reaction.
ISSN:	0022-3476
DOI:	10.1016/S0022-3476(84)80940-3