Ruellia angustiflora (Nees) Lindau ex Rambo: extraction and characterization of phenolic compounds and evaluation of antiradical, photoprotective and antimicrobial activities

• Published in: Natural product research Vol. 38; no. 12; pp. 2082 - 2090
• Main Authors: Zadra, Marina, Menezes, Bryan Brummelhaus de, Frescura, Lucas Mironuk, Essi, Liliana, Amaro de Carvalho, Camilo, Barcellos da Rosa, Marcelo
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17-06-2024; Taylor & Francis Ltd
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antibacterial activity; antimicrobial activity; Antioxidants - chemistry; Antioxidants - pharmacology; antiradical activity; Apiaceae - chemistry; DPPH-HPLC; Erythromycin; Ferulic acid; Microbial Sensitivity Tests; natural sunscreens; Phenolic compounds; Phenols; Phenols - chemistry; Phenols - pharmacology; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Leaves - chemistry; Plant Roots - chemistry; Plant Stems - chemistry; Quercetin; Ruellia; Ruellia angustiflora; Rutin; Streptococcus pyogenes - drug effects; antiradical activity; antimicrobial activity; natural sunscreens; DPPH-HPLC; Ruellia angustiflora
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2023.2244124

Ruellia angustiflora is a shrub popularly known as flower of fire, used in traditional medicine as a healing agent. This study aims to verify the presence of characteristics of pharmaceutical interest in extracts from the root, stem and leaves of this species. The ideal time for ultrasound-assisted extraction is 60 min with a solid-liquid ratio of 1% (w/v). The kinetics of the reaction of the extracts with DPPH is biphasic, and IC
50
values are related to the total phenolic compounds. Five phenolic compounds were identified in the extracts, where ferulic acid, rutin and quercetin showed to be the main responsible for the antiradical activity. The extracts displayed considerable photoprotective activity, mainly Ra-LE (SPF = 23). Ra-RE showed an inhibition halo similar to erythromycin against Streptococcus pyogenes. Taken together, these data reveal that Ruellia angustiflora is a source of phenolic compounds and has relevant antiradical, photoprotective and antibacterial activities.