Angiotensin-converting enzyme content of human spermatozoa and its release during capacitation

Angiotensin-converting enzyme content of human spermatozoa and its release during capacitation

In this study, we demonstrated, by using known detergents, the presence of angiotensin-converting enzyme (ACE) within human spermatozoa. We determined that maximal angiotensin-converting activity is expressed by sperm incubated in capacitating conditions, whereas this activity is negligible in salin...

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Bibliographic Details
Published in:Fertility and sterility Vol. 47; no. 6; p. 1000
Main Authors: Foresta, C, Indino, M, Manoni, F, Scandellari, C
Format: Journal Article
Language:English
Published: United States 01-06-1987
Subjects:
Adult
Fluorescent Antibody Technique
Humans
Male
Peptidyl-Dipeptidase A - analysis
Sperm Capacitation
Spermatozoa - enzymology
Time Factors
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Summary:In this study, we demonstrated, by using known detergents, the presence of angiotensin-converting enzyme (ACE) within human spermatozoa. We determined that maximal angiotensin-converting activity is expressed by sperm incubated in capacitating conditions, whereas this activity is negligible in saline-incubated spermatozoa. We further demonstrated that not acrosomes but cytoplasmic residues contain ACE. Because follicular fluid provides the necessary conditions for a maximal angiotensin-converting activity and for capacitations' metabolic activation, we hypothesize that ACE may play its physiologic role within the female reproductive tract.
ISSN:0015-0282
DOI:10.1016/S0015-0282(16)59236-X