Regional distribution of glutamate receptor mRNA in the monkey hippocampus and temporal cortex: influence of estradiol

• Published in: Brain research. Molecular brain research. Vol. 53; no. 1; pp. 328 - 332
• Main Authors: Kohama, Steven G, Garyfallou, Vasilios T, Urbanski, Henryk F
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 1998; Elsevier
• Subjects: AMPA; Animals; Biological and medical sciences; Central nervous system; Central neurotransmission. Neuromudulation. Pathways and receptors; Estradiol - pharmacology; Estrogen Replacement Therapy; Female; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - drug effects; Hippocampus - drug effects; Hippocampus - metabolism; In Situ Hybridization; Macaca mulatta; Neurons - metabolism; NMDA; Organ Specificity; Ovariectomy; Receptors, AMPA - biosynthesis; Receptors, N-Methyl-D-Aspartate - biosynthesis; RNA, Messenger - metabolism; Temporal Lobe - drug effects; Temporal Lobe - metabolism; Vertebrates: nervous system and sense organs; NMDA; In situ hybridization; AMPA; Vertebrata; Mammalia; Central nervous system; Distribution; Monkey; Primates; Temporal cortex; Glutamate receptor; Estradiol; Hippocampus; Brain (vertebrata)
• ISSN: 0169-328X; 1872-6941
• DOI: 10.1016/S0169-328X(97)00282-9

The distribution of
N-methyl-
d-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) glutamate receptor subunits was examined in the hippocampus and temporal cortex of adult ovariectomized female rhesus macaques, some of which received estradiol replacement. In situ hybridization revealed a generalized overlap of NR1, GluR1, and GluR2 subunit mRNAs, but no effect due to estradiol treatment. However, regional differences in expression were noted for each subunit.