Small cell undifferentiated carcinoma of the colon associated with hepatocellular carcinoma in an immunodeficient patient

• Published in: Human pathology Vol. 27; no. 9; pp. 992 - 996
• Main Authors: Zirkin, Howard J, Levy, Jacov, Katchko, Leonid
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-09-1996; Elsevier
• Subjects: Adult; Biological and medical sciences; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - surgery; Carcinoma, Hepatocellular - ultrastructure; Carcinoma, Small Cell - pathology; Carcinoma, Small Cell - surgery; Carcinoma, Small Cell - ultrastructure; Colonic Neoplasms - pathology; Colonic Neoplasms - surgery; Colonic Neoplasms - ultrastructure; Follow-Up Studies; Gastroenterology. Liver. Pancreas. Abdomen; hepatocellular carcinoma; Humans; Hypergammaglobulinemia - pathology; Immunoglobulin M; Immunologic Deficiency Syndromes - pathology; Liver Neoplasms - pathology; Liver Neoplasms - surgery; Liver Neoplasms - ultrastructure; Male; Medical sciences; Neoplasms, Multiple Primary - pathology; Neoplasms, Multiple Primary - surgery; Neoplasms, Multiple Primary - ultrastructure; neuroendocrine tumor; oat cell carcinoma; Omentum; small cell undifferentiated carcinoma of colon; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tropical medicine; Tumors; X-linked hyper-IgM syndrome; IMIG; small cell undifferentiated carcinoma of colon; NSAID; AIDS; X-linked hyper-IgM syndrome; SCUC-C; WIG; HIV; ANC; neuroendocrine tumor; ANF; hepatocellular carcinoma; Ig; PCR; oat cell carcinoma; Human; Immunohistochemistry; Immunopathology; Hepatic disease; Malignant tumor; Electron microscopy; Immune deficiency; Genetic disease; Colonic disease; Case study; Pathology; Concomitant disease; Liver cell carcinoma; Young adult; Digestive diseases; Colon; Oat cell carcinoma
• ISSN: 0046-8177; 1532-8392
• DOI: 10.1016/S0046-8177(96)90232-4

Small cell undifferentiated carcinoma (oat cell carcinoma) is a malignant epithelial neoplasm with neuroendocrine features. It can appear as a primary tumor in many organs besides the lung, including the colon. We report a case of primary small cell undifferentiated carcinoma of the left colon with omental metastases in a 23-year-old man with a history of X-linked hyper-IgM syndrome. The patient had a simultaneous primary hepatocellular carcinoma. A literature review of this rare colonic malignancy is presented together with a discussion of the possible relationship of this tumor with hepatic malignancy and immunodeficiency.