Angiotensin II signal transduction pathways

• Published in: Regulatory Peptides Vol. 78; no. 1; pp. 19 - 29
• Main Authors: Sayeski, Peter P., Ali, M.Showkat, Semeniuk, Dan J., Doan, Thanh N., Bernstein, Kenneth E.
• Format: Book Review Journal Article
• Language: English
• Published: Shannon Elsevier B.V 30-11-1998; Amsterdam Elsevier
• Subjects: Amino Acid Sequence; Angiotensin II - metabolism; Angiotensin II - physiology; Biological and medical sciences; Cell Adhesion Molecules - metabolism; Effector molecule; Endocrine kidney. Renin-angiotensin-aldosterone system; Focal Adhesion Protein-Tyrosine Kinases; Fundamental and applied biological sciences. Psychology; GTP-Binding Proteins - metabolism; Heterotrimeric G protein; Molecular Sequence Data; Phosphorylation; Protein-Tyrosine Kinases - metabolism; Receptors, Angiotensin - metabolism; Renin; Renin-Angiotensin System - physiology; Renin–angiotensin system; Signal Transduction - physiology; Signal transduction pathways; Structure-Activity Relationship; Tyrosine - metabolism; Tyrosine phosphorylation; Vertebrates: endocrinology; Renin–angiotensin system; Signal transduction pathways; Heterotrimeric G protein; Renin; Effector molecule; Tyrosine phosphorylation; Peptidases; Signal transduction; Renin angiotensin system; Enzyme; Hydrolases; Aspartic endopeptidases; Review; Angiotensin II; Biological receptor; Hormonal receptor
• ISSN: 0167-0115; 1873-1686
• DOI: 10.1016/S0167-0115(98)00137-2

It has been 100 years since the discovery of renin by Tigerstedt and Bergman. Since that time, numerous discoveries have advanced our understanding of the renin–angiotensin system, including the observation that angiotensin II is the effector molecule of this system. A remarkable aspect of angiotensin II is the many different physiological responses this simple peptide induces in different cell types. Here, we focus on the signal transduction pathways that are activated as a consequence of angiotensin II binding to the AT
1 receptor. Classical signaling pathways such as the activation of heterotrimeric G proteins by the AT
1 receptor are discussed. In addition, recent work examining the role of tyrosine phosphorylation in angiotensin II-mediated signal transduction is also examined. Understanding how these distinct signaling pathways transduce signals from the cell surface will advance our understanding of how such a simple molecule elicits such a wide variety of specific cellular responses.