Preoperative inflammation is a prognostic factor for gallbladder carcinoma

• Published in: British journal of surgery Vol. 98; no. 1; pp. 111 - 116
• Main Authors: Han, H.-S., Cho, J. Y., Yoon, Y.-S., Ahn, K. S., Kim, H.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01-01-2011; Wiley
• Subjects: Adult; Aged; Biological and medical sciences; Blood Loss, Surgical; Carcinoma in Situ - complications; Carcinoma in Situ - mortality; Carcinoma in Situ - surgery; Cholecystitis - complications; Cholecystitis - mortality; Cholecystitis - surgery; Female; Gallbladder Neoplasms - complications; Gallbladder Neoplasms - mortality; Gallbladder Neoplasms - surgery; General aspects; Humans; Male; Medical sciences; Middle Aged; Neoplasm Recurrence, Local - diagnosis; Neoplasm Recurrence, Local - mortality; Preoperative Care; Prognosis; Retrospective Studies; Survival Analysis; Medicine; Carcinoma; Prognosis; Treatment; Digestive system; Surgery; Gallbladder; Inflammation; Malignant tumor; Preoperative; Cancer
• ISSN: 0007-1323; 1365-2168
• DOI: 10.1002/bjs.7265

Background:
Inflammation frequently accompanies gallbladder carcinoma (GBC), but its impact on outcome is unclear. The present study investigated the impact of concomitant inflammation on survival of patients with GBC.
Methods:
All patients undergoing surgery for GBC between October 2003 and May 2009 were identified retrospectively from a prospectively collected database. Patients were classified according to whether preoperative inflammation was present (65 patients) or not (23).
Results:
A total of 88 patients were enrolled. There were no differences in sex, mean age, tumour node metastasis (TNM) stage and radicality of resection between the two groups. The overall 3‐year survival rate was lower in patients with preoperative inflammation than in those without (33 versus 73 per cent; P = 0·001). In univariable analysis, preoperative inflammation, T, N and M category, TNM stage, radicality of surgery and tumour differentiation were significant prognostic factors. The presence of preoperative inflammation (hazard ratio (HR) 2·38, 95 per cent confidence interval 1·04 to 5·43), lymph node metastases (HR 5·23, 1·05 to 26·09) and R1 or R2 resection (HR 3·77, 1·47 to 9·72) were independent prognostic factors for poor survival.
Conclusion:
The presence of preoperative inflammation is an independent prognostic factor for poor survival in patients with GBC. Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
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