Identification of new B27 subtypes (B27C and B27D) prevalent in oriental populations

• Published in: Human immunology Vol. 16; no. 2; p. 163
• Main Authors: Breur-Vriesendorp, B S, Neefjes, J C, Huis, B, van Seventer, G A, Ploegh, H L, Iványi, P
• Format: Journal Article
• Language: English
• Published: United States 01-06-1986
• Subjects: Asian Continental Ancestry Group; China - ethnology; Cross Reactions; Cross-Sectional Studies; European Continental Ancestry Group; HLA Antigens - analysis; HLA Antigens - classification; HLA Antigens - genetics; HLA-B27 Antigen; HLA-C Antigens; Humans; Indonesia - ethnology; Isoelectric Focusing - methods; Japan - ethnology; Lymphocyte Culture Test, Mixed - methods; T-Lymphocytes, Cytotoxic - immunology; China; Japan; Indonesia
• ISSN: 0198-8859
• DOI: 10.1016/0198-8859(86)90045-5

With the aid of alloreactive cytotoxic T lymphocytes, three subtypes of HLA-B27 can be defined: B27W, B27K, and B27C (non-B27W and non-B27K). The B27C subtype can be distinguished by 1D-IEF, is not recognized by B27W- or B27K-restricted influenza-A-specific cytotoxic T lymphocytes, and is prevalent in Oriental populations. Preliminary data indicate that the various B27 subtypes (W, K, C) are in different linkage disequilibria with HLA-C antigens. A fourth subtype of B27 (non-B27W and non-B27K), designated as B27D, was detected by 1D-IEF. (See accompanying paper by Neefjes et al.) The finding of four B27 subtypes indicates that the serologically defined B27 antigen comprises a family of various, strongly cross-reactive class-I molecules.