Extreme central acidosis from Abbott epinephrine

Investigation into the cause of extreme systemic acidosis during cardiac arrest led to the discovery that a major contributing factor was Abbott 1:10,000 single-dose epinephrine, which contained a large unsuspected acid level. Analysis of this product, both in vivo and in vitro, demonstrated that it...

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Bibliographic Details
Published in:	The American journal of medicine Vol. 74; no. 1; p. 30
Main Authors:	Feldschuh, J, Gambino, R
Format:	Journal Article
Language:	English
Published:	United States 01-01-1983
Subjects:	Acidosis - chemically induced Epinephrine - administration & dosage Epinephrine - adverse effects Epinephrine - analysis Heart Arrest - blood Heart Arrest - drug therapy Humans Hydrogen-Ion Concentration
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Summary:	Investigation into the cause of extreme systemic acidosis during cardiac arrest led to the discovery that a major contributing factor was Abbott 1:10,000 single-dose epinephrine, which contained a large unsuspected acid level. Analysis of this product, both in vivo and in vitro, demonstrated that it contained 8.2 times the acid content of a presumably identical product from Bristol Laboratories and also of a presumably identical product from Bristol Laboratories and also 1,850 times the acid content of an identical epinephrine dose made from a Parke-Davis preparation. Abbott epinephrine injected into the central circulation or directly into the heart causes extreme acidemia, which may be potentially lethal by itself when superimposed on pre-existing acidosis as in cardiac arrest.
ISSN:	0002-9343
DOI:	10.1016/0002-9343(83)91114-2