Translocation 5;21 and interstitial deletion of chromosome 7 in a case of chronic myelomonocytic leukemia

We report a case of chronic myelomonocytic leukemia with a translocation involving chromosome 5 and 21, namely, t(5;21)(q35.3;q22.1), and an interstitial deletion of the long arm of chromosome 7. High-resolution analysis at the 900-band stage has shown that the lesion in chromosome 7 is an interstit...

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Bibliographic Details
Published in:	Cancer genetics and cytogenetics Vol. 31; no. 2; p. 247
Main Authors:	Sherrington, P D, Nacheva, E, Fischer, P, Rees, J K, Hoyle, C, Dyer, M, Harper, P, Knight, C, Hayhoe, F G
Format:	Journal Article
Language:	English
Published:	United States 01-04-1988
Subjects:	Aged Aged, 80 and over Chromosome Banding Chromosome Deletion Chromosomes, Human, Pair 21 Chromosomes, Human, Pair 5 Chromosomes, Human, Pair 7 Genetic Markers Humans Karyotyping Leukemia, Myeloid - genetics Male Translocation, Genetic
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Summary:	We report a case of chronic myelomonocytic leukemia with a translocation involving chromosome 5 and 21, namely, t(5;21)(q35.3;q22.1), and an interstitial deletion of the long arm of chromosome 7. High-resolution analysis at the 900-band stage has shown that the lesion in chromosome 7 is an interstitial deletion involving loss of the segments q22-q35 of the long arm of chromosome 7 and retaining the telomere.
ISSN:	0165-4608
DOI:	10.1016/0165-4608(88)90224-5