Pretreatment prognostic factors in patients with early-stage (I/II) non-small-cell lung cancer treated with hyperfractionated radiation therapy alone

• Published in: International journal of radiation oncology, biology, physics Vol. 65; no. 4; p. 1112
• Main Authors: Jeremić, Branislav, Milicić, Biljana, Dagović, Aleksandar, Acimović, Ljubisa, Milisavljević, Slobodan
• Format: Journal Article
• Language: English
• Published: United States 15-07-2006
• Subjects: Analysis of Variance; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - radiotherapy; Dose Fractionation; Female; Humans; Karnofsky Performance Status; Lung Neoplasms - pathology; Lung Neoplasms - radiotherapy; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local - pathology; Prognosis; Retrospective Studies; Survival Analysis
• ISSN: 0360-3016
• DOI: 10.1016/j.ijrobp.2006.01.044

To investigate influence of various pretreatment prognostic factors in patients with early stage (I/II) non-small-cell lung cancer (NSCLC) treated with hyperfractionated radiation therapy alone.
One hundred and sixteen patients were treated with tumor doses of 69.6 Gy, 1.2-Gy, twice-daily fractionation. There were 49 patients with Stage I and 67 patients with Stage II. Eighty patients had Karnofsky performance status (KPS) 90-100 and 95 patients had <5% weight loss. Peripheral tumors were observed in 57 patients. Squamous histology was observed in 70 patients and the majority of patients had concomitant disease (n=72).
The median survival time for all patients was 29 months; 5-year survival was 29%. The median time to local progression and the distant metastasis were not achieved, whereas 5-year local progression-free and distant metastasis-free survivals were 50% and 72%, respectively. Multivariate analysis identified KPS, weight loss, location, histology, and the reason for not undergoing surgery as prognostic factors for survival. KPS, location, and histology influenced local progression-free survival, whereas only KPS and weight loss influenced distant metastasis-free survival.
This retrospective analysis identified KPS and weight loss as the most important prognostic factors of outcome in patients with early-stage NSCLC treated with hyperfractionation radiation therapy.