Lin28 gene and mammalian puberty

• Published in: Molecular reproduction and development Vol. 87; no. 5; pp. 525 - 533
• Main Authors: Cao, Guiling, Gao, Zeyang, Jiang, Yunliang, Chu, Mingxing
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-05-2020
• Subjects: expression pattern; Gene expression; gene mutation; Genomes; glucose metabolism; Lin28a; Lin28b; onset of puberty; Pluripotency; Puberty; Tumorigenicity; Lin28a; Lin28b; expression pattern; onset of puberty; glucose metabolism; gene mutation
• ISSN: 1040-452X; 1098-2795
• DOI: 10.1002/mrd.23347

Lin28a and Lin28b, homologs of the Caenorhabditis elegans Lin28 gene, play important roles in cell pluripotency, reprogramming, and tumorigenicity. Recently, genome‐wide association and transgenic studies showed that Lin28a and/or Lin28b gene were involved in the onset of mammalian puberty, the stage representing the attainment of reproduction capacity; however, the detailed mechanism of these genes in mammalian puberty remains largely unknown. The present paper reviews the research progress on the roles of Lin28a/b genes in the onset of mammalian puberty by analyzing the results coming from gene expression patterns, mutations, and transgenic studies, and put forward possible pathways for further studies on their roles in animal reproduction.
Recently, some studies showed that Lin28a/b gene was involved in the onset of mammalian puberty, but, the detailed mechanism of them in mammalian puberty remains largely unknown. the research progress on the roles of Lin28a/b in the onset of mammalian puberty by analyzing the results coming from gene expression pattern, mutations, and transgenic studies.