Physiological stress response patterns during a blood donation

• Published in: Vox sanguinis Vol. 113; no. 4; pp. 357 - 367
• Main Authors: Hoogerwerf, M. D., Veldhuizen, I. J. T., Tarvainen, M. P., Merz, E.‐M., Huis in ‘t Veld, E. M. J., Kort, W. L. A. M., Sluiter, J. K., Frings‐Dresen, M. H. W.
• Format: Journal Article
• Language: English
• Published: England S. Karger AG 01-05-2018
• Subjects: Adult; Blood & organ donations; Blood Donors; Blood Pressure; Female; Group effects; Heart Rate; Humans; Insertion; Male; Physiology; Psychological stress; Stress (physiology); Stress response; Stress, Physiological; Stress, Psychological - etiology; Time domain analysis; blood donors; blood pressure; heart rate; stress, physiological
• ISSN: 0042-9007; 1423-0410
• DOI: 10.1111/vox.12646

Background
Donating blood is associated with increased psychological stress. This study investigates whether a blood donation induces physiological stress and if response patterns differ by gender, donation experience and non‐acute stress.
Study design and methods
In 372 donors, physiological stress [blood pressure, pulse rate, pulse rate variability (PRV)] was measured at seven moments during routine donation. PRV was assessed using time domain [root mean square of successive differences (RMSSD)] and frequency domain [high frequency (HF) and low frequency (LF) power] parameters. Non‐acute stress was assessed by questionnaire. Shape and significance of time course patterns were assessed by fitting multilevel models for each stress measure and comparing men and women, first‐time and experienced donors, and donors with high and low levels of non‐acute stress.
Results
Significant response patterns were found for all stress measures, where levels of systolic blood pressure (F(1,1315) = 24·2, P < 0·001), RMSSD (F(1,1315) = 24·2, P < 0·001), LF (F(1,1627) = 14·1, P < 0·001) and HF (F(1,1624) = 34·0, P < 0·001) increased towards needle insertion and then decreased to values lower than when arriving at the donation centre. Diastolic blood pressure (F(1,1326) = 50·9, P < 0·001) increased and pulse rate (F(1,1393) = 507·4, P < 0·001) showed a U‐shaped curve. Significant group effects were found, that is, higher systolic blood pressure/pulse rate in women; higher pulse rate in first‐time donors; higher RMSSD at arrival and from screening until leaving in first‐time donors; and higher LF and HF in first‐time donors.
Conclusion
This study shows an increase in physiological stress related to needle insertion, followed by a decrease when leaving the donation centre. Some group effects were also found.